机构:
Kuopio Univ Hosp, Neuro Ctr, Neurol Outpatient Clin, POB 100, FI-70029 Kuopio, FinlandKuopio Univ Hosp, Neuro Ctr, Neurol Outpatient Clin, POB 100, FI-70029 Kuopio, Finland
Hartikainen, Paivi
[1
]
Huber, Nadine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio, FinlandKuopio Univ Hosp, Neuro Ctr, Neurol Outpatient Clin, POB 100, FI-70029 Kuopio, Finland
Huber, Nadine
[4
]
Solje, Eino
论文数: 0引用数: 0
h-index: 0
机构:
Kuopio Univ Hosp, Neuro Ctr, Neurol Outpatient Clin, POB 100, FI-70029 Kuopio, Finland
Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, FinlandKuopio Univ Hosp, Neuro Ctr, Neurol Outpatient Clin, POB 100, FI-70029 Kuopio, Finland
Solje, Eino
[1
,2
]
Haapasalo, Annakaisa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio, FinlandKuopio Univ Hosp, Neuro Ctr, Neurol Outpatient Clin, POB 100, FI-70029 Kuopio, Finland
Haapasalo, Annakaisa
[4
]
Kokkola, Tarja
论文数: 0引用数: 0
h-index: 0
机构:
Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, FinlandKuopio Univ Hosp, Neuro Ctr, Neurol Outpatient Clin, POB 100, FI-70029 Kuopio, Finland
Kokkola, Tarja
[2
]
Lohioja, Tarja
论文数: 0引用数: 0
h-index: 0
机构:
Kuopio Univ Hosp, Neuro Ctr, Neurol Outpatient Clin, POB 100, FI-70029 Kuopio, FinlandKuopio Univ Hosp, Neuro Ctr, Neurol Outpatient Clin, POB 100, FI-70029 Kuopio, Finland
Lohioja, Tarja
[1
]
Herukka, Sanna-Kaisa
论文数: 0引用数: 0
h-index: 0
机构:
Kuopio Univ Hosp, Neuro Ctr, Neurol Outpatient Clin, POB 100, FI-70029 Kuopio, Finland
Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, FinlandKuopio Univ Hosp, Neuro Ctr, Neurol Outpatient Clin, POB 100, FI-70029 Kuopio, Finland
Herukka, Sanna-Kaisa
[1
,2
]
Simula, Sakari
论文数: 0引用数: 0
h-index: 0
机构:
Mikkeli Cent Hosp, Dept Neurol, Mikkeli, FinlandKuopio Univ Hosp, Neuro Ctr, Neurol Outpatient Clin, POB 100, FI-70029 Kuopio, Finland
Simula, Sakari
[5
]
Remes, Anne M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oulu, Unit Clin Neurosci, Neurol, Oulu, Finland
Oulu Univ Hosp, Med Res Ctr, Oulu, FinlandKuopio Univ Hosp, Neuro Ctr, Neurol Outpatient Clin, POB 100, FI-70029 Kuopio, Finland
Remes, Anne M.
[6
,7
]
机构:
[1] Kuopio Univ Hosp, Neuro Ctr, Neurol Outpatient Clin, POB 100, FI-70029 Kuopio, Finland
[2] Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland
[3] Kuopio Univ Hosp, Sci Serv Ctr, Kuopio, Finland
[4] Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio, Finland
[5] Mikkeli Cent Hosp, Dept Neurol, Mikkeli, Finland
[6] Univ Oulu, Unit Clin Neurosci, Neurol, Oulu, Finland
Objective: We aimed to investigate serum glial fibrillary acidic protein (GFAP) and serum neurofilament light chain (NfL) levels as potential discriminative biomarkers between benign relapsing-remitting multiple sclerosis (BRRMS) and aggressive relapsing-remitting MS (ARRMS). Methods: Serum GFAP and NfL levels were analyzed in patients with BRRMS (n = 34), ARRMS (n = 29), and healthy controls (n = 14) by using Single Molecule Array (Simoa). Patients with ARRMS had been treated with highly effective disease-modifying treatments (DMT) (fingolimod or natalizumab). Results: Serum GFAP levels in both BRRMS (median 210.19 pg/ml, IQR 163.69-287.19) and in ARRMS (median 188.60 pg/ml, IQR39.23-244.93) were significantly higher (p = 0.035 and p = 0.034, respectively) compared to healthy controls (median 117.93 pg/ml, IQR 60.28-183.83). Serum GFAP levels did not differ between BRRMS and ARRMS. There were no statistical differences in NfL levels between BRRMS, ARRMS and healthy controls. GFAP level was significantly higher (p = 0.04) in BRRMS without DMT (median 216.04 pg/ml, IQR 188.60-274.79) than in those BRRMS patients who had used DMT (median 196.26 pg/ml, IQR 133.33-325.54). Conclusions: We found elevated levels of serum GFAP in both BRRMS and ARRMS compared to healthy controls, reflecting astrocytic activation. Serum NfL did not differ between BRRMS and ARRMS, probably due to the stable inflammatory phase of the disease and effective DMT use in ARRMS. Single serum NfL and GFAP measurements cannot separate a patient with BRRMS from effectively treated ARRMS after a long history of the disease, thus consecutive samples are needed in the follow-up.
机构:
Santa Casa Sao Paulo, Fac Ciencias Med, Neurol Clin, Ctr Atendimento & Tratamento Esclerose Multipla, Sao Paulo, BrazilSanta Casa Sao Paulo, Fac Ciencias Med, Neurol Clin, Ctr Atendimento & Tratamento Esclerose Multipla, Sao Paulo, Brazil
Mendes, MF
Tilbery, CP
论文数: 0引用数: 0
h-index: 0
机构:
Santa Casa Sao Paulo, Fac Ciencias Med, Neurol Clin, Ctr Atendimento & Tratamento Esclerose Multipla, Sao Paulo, BrazilSanta Casa Sao Paulo, Fac Ciencias Med, Neurol Clin, Ctr Atendimento & Tratamento Esclerose Multipla, Sao Paulo, Brazil
Tilbery, CP
Balsimelli, S
论文数: 0引用数: 0
h-index: 0
机构:
Santa Casa Sao Paulo, Fac Ciencias Med, Neurol Clin, Ctr Atendimento & Tratamento Esclerose Multipla, Sao Paulo, BrazilSanta Casa Sao Paulo, Fac Ciencias Med, Neurol Clin, Ctr Atendimento & Tratamento Esclerose Multipla, Sao Paulo, Brazil
Balsimelli, S
Felipe, E
论文数: 0引用数: 0
h-index: 0
机构:
Santa Casa Sao Paulo, Fac Ciencias Med, Neurol Clin, Ctr Atendimento & Tratamento Esclerose Multipla, Sao Paulo, BrazilSanta Casa Sao Paulo, Fac Ciencias Med, Neurol Clin, Ctr Atendimento & Tratamento Esclerose Multipla, Sao Paulo, Brazil
Felipe, E
Moreira, MA
论文数: 0引用数: 0
h-index: 0
机构:
Santa Casa Sao Paulo, Fac Ciencias Med, Neurol Clin, Ctr Atendimento & Tratamento Esclerose Multipla, Sao Paulo, BrazilSanta Casa Sao Paulo, Fac Ciencias Med, Neurol Clin, Ctr Atendimento & Tratamento Esclerose Multipla, Sao Paulo, Brazil
Moreira, MA
Barao-Cruz, AM
论文数: 0引用数: 0
h-index: 0
机构:
Santa Casa Sao Paulo, Fac Ciencias Med, Neurol Clin, Ctr Atendimento & Tratamento Esclerose Multipla, Sao Paulo, BrazilSanta Casa Sao Paulo, Fac Ciencias Med, Neurol Clin, Ctr Atendimento & Tratamento Esclerose Multipla, Sao Paulo, Brazil