Solvent effect on copper-catalyzed azide-alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents

被引：26
|
作者：
Ellanki, Amarender Reddy [2 ,5 ]
Islam, Aminul [2 ]
Rama, Veera Swamy [2 ]
Pulipati, Ranga Prasad [2 ]
Rambabu, D. [1 ,3 ]
Krishna, G. Rama [4 ]
Reddy, C. Malla [4 ]
Mukkanti, K. [5 ]
Vanaja, G. R. [6 ]
Kalle, Arunasree M. [6 ]
Kumar, K. Shiva [1 ]
Pal, Manojit [1 ]
机构：
[1] Inst Life Sci, Hyderabad 500046, Andhra Pradesh, India
[2] Dr Reddys Labs Ltd, Chem Technol Dev Ctr, Hyderabad 500049, Andhra Pradesh, India
[3] KL Univ, Dept Chem, Guntur 522502, Andhra Pradesh, India
[4] Indian Inst Sci Educ & Res, Dept Chem Sci, Kolkata 741252, W Bengal, India
[5] JNT Univ, Inst Sci & Technol, Div Chem, Hyderabad 500072, Andhra Pradesh, India
[6] Univ Hyderabad, Sch Life Sci, Dept Anim Sci, Hyderabad 500046, Andhra Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 10期
关键词：
Click chemistry; Azide; Alkyne; Quinoline; Cancer; CLICK CHEMISTRY; 1,3-DIPOLAR CYCLOADDITIONS; EFFICIENT;
D O I：
10.1016/j.bmcl.2012.03.091
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A regioselective route to novel mono triazolyl substituted quinolines has been developed via copper-catalyzed azide-alkyne cycloaddition (CuAAC) of 2,4-diazidoquinoline with terminal alkynes in DMF. The reaction provided bis triazolyl substituted quinolines when performed in water in the presence of Et3N. A number of the compounds synthesized showed promising anti-proliferative properties when tested in vitro especially against breast cancer cells. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3455 / 3459
页数：5
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