Severe Hemolytic Transfusion Reaction Due to Anti-D in a D plus Patient With Sickle Cell Disease

被引:16
|
作者
Ipe, Tina S. [1 ]
Wilkes, Jennifer J. [2 ]
Hartung, Helge D. [2 ]
Westhoff, Connie M. [4 ]
Chou, Stella T. [2 ]
Friedman, David F. [2 ,3 ]
机构
[1] Houston Methodist Hosp, Dept Pathol, Houston, TX USA
[2] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA
[3] Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[4] New York Blood Ctr, Immunohematol & Genom Lab, New York, NY 10021 USA
关键词
sickle cell disease; red blood cell transfusion; alloimmunization; delayed hemolytic transfusion reaction; RH genotype; DIRECT ANTIGLOBULIN-TEST; ALLOIMMUNIZATION; PREVALENCE;
D O I
10.1097/MPH.0000000000000241
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation demonstrated severe anemia, blood type O+, and anti-D in the serum. Anti-D in a D+ patient led to RH genotyping, which revealed homozygosity for RHD*DAU4 that encodes partial D antigen. Anti-D in this patient whose RBCs exclusively express partial D caused a delayed hemolytic transfusion reaction after exposure to D+ RBCs. The finding of anti-D in a D+ patient should be investigated by molecular methods to help distinguish an alloantibody from an autoantibody.
引用
收藏
页码:E135 / E137
页数:3
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