Severe Hemolytic Transfusion Reaction Due to Anti-D in a D plus Patient With Sickle Cell Disease

被引：16

作者：

Ipe, Tina S. ^{[1
]}

Wilkes, Jennifer J. ^{[2
]}

Hartung, Helge D. ^{[2
]}

Westhoff, Connie M. ^{[4
]}

Chou, Stella T. ^{[2
]}

Friedman, David F. ^{[2
,3
]}

机构：

[1] Houston Methodist Hosp, Dept Pathol, Houston, TX USA

[2] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

[3] Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[4] New York Blood Ctr, Immunohematol & Genom Lab, New York, NY 10021 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2015年 / 37卷 / 02期

关键词：

sickle cell disease; red blood cell transfusion; alloimmunization; delayed hemolytic transfusion reaction; RH genotype; DIRECT ANTIGLOBULIN-TEST; ALLOIMMUNIZATION; PREVALENCE;

D O I：

10.1097/MPH.0000000000000241

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation demonstrated severe anemia, blood type O+, and anti-D in the serum. Anti-D in a D+ patient led to RH genotyping, which revealed homozygosity for RHD*DAU4 that encodes partial D antigen. Anti-D in this patient whose RBCs exclusively express partial D caused a delayed hemolytic transfusion reaction after exposure to D+ RBCs. The finding of anti-D in a D+ patient should be investigated by molecular methods to help distinguish an alloantibody from an autoantibody.

引用

页码：E135 / E137

页数：3

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