Microwave-assisted synthesis of 2,5-disubstituted pyrimidine derivatives via Buchwald-Hartwig amination

被引：8
|
作者：
Li, Bo [1 ]
Etheve-Quelquejeu, Melanie [1 ]
Yen-Pon, Expedite [1 ]
Garbay, Christiane [1 ]
Chen, Huixiong [1 ]
机构：
[1] Univ Paris 05, CNRS, UMR8601, Chem RNA,Nucleosides Peptides & Heterocycles, 45 Rue St Peres, F-75006 Paris, France
来源：
TETRAHEDRON LETTERS | 2020年 / 61卷 / 03期
关键词：
Pyrimidine; Pd-catalyzed; C-N cross-coupling; Microwave synthesis; INHIBITORS; POTENT;
D O I：
10.1016/j.tetlet.2019.151406
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Various 2,5-disubstituted pyrimidine derivatives were synthesized under microwave irradiation via Buchwald-Hartwig amination. This concise approach provides interesting scaffolds in good to high yields and with large functional group compatibility. These novel chemical entities could be used as building blocks in drug design. (C) 2019 Elsevier Ltd. All rights reserved.
引用
收藏
页数：4
相关论文
共 50 条
  • [41] A FACILE SYNTHESIS OF 2,5-DISUBSTITUTED INDOLE DERIVATIVES AS NEW FLUORESCENT DYES
    Hiyoshi, Hidetaka
    Do, Jung-Hee
    Feng, Xing
    Matsumoto, Taisuke
    Yamato, Takehiko
    HETEROCYCLES, 2011, 83 (05) : 1017 - 1027
  • [42] Microwave-assisted synthesis and biological activity of 2,5-disubstituted-1,3,4-thiadiazole
    Yu Yuye
    ASIAN JOURNAL OF CHEMISTRY, 2007, 19 (04) : 3141 - 3144
  • [43] Synthesis of phenazines from ortho-bromo azo compounds via sequential Buchwald-Hartwig amination under micellar conditions and acid promoted cyclization
    Yousif, Dawod
    Monti, Mauro
    Papagni, Antonio
    Vaghi, Luca
    TETRAHEDRON LETTERS, 2020, 61 (46)
  • [44] Controlled and Efficient Stereoselective Synthesis of Oxindole-Appended 1-Aza-1,3-butadiene Derivatives via a One-Pot Buchwald-Hartwig Amination/Elimination Strategy
    Lingam, Kandapalam Arun Prasath
    Amutha, Periyasamy
    Yuvaraj, Paneerselvam
    Selvakumar, Kodirajan
    SYNTHESIS-STUTTGART, 2018, 50 (03): : 599 - 606
  • [45] Synthesis of Au-Pd@CeO2 nanocomposite as a potential catalyst for the Buchwald-Hartwig cross-coupling and amination of benzyl alcohol reactions
    Kulkarni, Padmakar A.
    Kahandal, Sandeep S.
    Awale, Ashok G.
    Bhangoji, Jagdish C.
    Shendage, Suresh S.
    JOURNAL OF CHEMICAL SCIENCES, 2024, 136 (02)
  • [46] Microwave-assisted synthesis of 3,5-disubstituted isoxazoles and evaluation of their anti-ageing activity
    Koufaki, Maria
    Fotopoulou, Theano
    Kapetanou, Marianna
    Heropoulos, Georgios A.
    Gonos, Efstathios S.
    Chondrogianni, Niki
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 83 : 508 - 515
  • [47] Microwave assisted one-pot synthesis of some 2,5-disubstituted 1,3,4-oxadiazoles
    Kalluraya, B.
    Rao, Jyothi N.
    Sujith, K. V.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2008, 17 (04) : 359 - 362
  • [48] Microwave-Assisted Solvent-Free Synthesis of Highly Functionalized Pyrimidine Derivatives
    Yan, Shengjiao
    Niu, Yanfei
    Chen, Xuebing
    Liu, Yongjiang
    Lin, Jun
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2012, 49 (04) : 877 - 882
  • [49] FACILE SYNTHESIS OF 2,5-DISUBSTITUTED FURAN-DERIVATIVES AND ITS APPLICATION FOR THE SYNTHESIS OF PYRETHROID
    TADA, M
    AKIYAMA, S
    SUDA, M
    HASHIZUME, T
    AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1982, 46 (01): : 291 - 292
  • [50] Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3-d]pyrimidine Analogues As Antifolates; Application of Buchwald-Hartwig Aminations of Heterocycles
    Gangjee, Aleem
    Namjoshi, Ojas A.
    Raghavan, Sudhir
    Queener, Sherry F.
    Kisliuk, Roy L.
    Cody, Vivian
    JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (11) : 4422 - 4441
12345