Microwave-Assisted Solvent-Free Synthesis of Highly Functionalized Pyrimidine Derivatives

被引：4

作者：

Yan, Shengjiao ^{[1
]}

Niu, Yanfei ^{[1
]}

Chen, Xuebing ^{[1
]}

Liu, Yongjiang ^{[1
]}

Lin, Jun ^{[1
]}

机构：

[1] Yunnan Univ, Minist Educ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resources, Kunming 650091, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2012年 / 49卷 / 04期

关键词：

REVERSE-TRANSCRIPTASE INHIBITORS; RECEPTOR ANTAGONISTS; WILD-TYPE; DISCOVERY; POTENT; 2,4-DIAMINOPYRIMIDINES; N; S-ACETALS; CHEMISTRY; GUANIDINE; DESIGN;

D O I：

10.1002/jhet.891

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We here described an efficient method for the synthesis of a series of highly functionalized pyrimidines via the addition and condensation reaction of ketene dithioacetals with guanidine carbonate or amidine hydrochlorides by microwave irradiation under solvent-free conditions in the absence of a catalyst, giving the products with good yields (7998%).

引用

页码：877 / 882

页数：6

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