Microwave-assisted solvent-free parallel synthesis of thioamides

被引：45
|
作者：
Olsson, R [1 ]
Hansen, HC [1 ]
Andersson, CM [1 ]
机构：
[1] ACADIA Pharmaceut AS, Synthet Chem, DK-2600 Glostrup, Denmark
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 41期
关键词：
microwave; parallel synthesis; thioamide;
D O I：
10.1016/S0040-4039(00)01360-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Rapid parallel synthesis of thioamides is described. A library of amides, synthesised by mixing acyl chlorides and diamines, was transformed into the corresponding thioamides utilising Lawesson's reagent as the oxygen/sulphur exchange reagent. Purification by solid-phase extraction afforded the library members in adequate purities and yields. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7947 / 7950
页数：4
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