Mesoscale porous silica as drug delivery vehicles: Synthesis, characterization, and pH-sensitive release profiles

被引：58
|
作者：
DeMuth, Peter [1 ]
Hurley, Matthew [1 ]
Wu, Chunwei [2 ]
Galanie, Stephanie [1 ]
Zachariah, Michael R. [1 ,2 ]
DeShong, Philip [1 ]
机构：
[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA
[2] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA
来源：
MICROPOROUS AND MESOPOROUS MATERIALS | 2011年 / 141卷 / 1-3期
基金：
美国国家科学基金会;
关键词：
Mesoporous silica nanoparticles; Controlled release; pH responsive; MESOPOROUS MOLECULAR-SIEVES; OPERATED MECHANIZED NANOPARTICLES; RESPONSIVE CONTROLLED-RELEASE; PORE-SIZE; GUEST MOLECULES; SYSTEM; MCM-41; OPTIMIZATION; SILANIZATION; NANOSPHERE;
D O I：
10.1016/j.micromeso.2010.10.035
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Mesoporous silica nanoparticles (MSN) have potential as drug delivery and controlled release devices due to their high surface area and absorption capabilities. The effect of surface charge and pH on the release of the fluorescent dye, rhodamine 6G, from MSN has been studied. Release profiles of rhodamine 6G from bare and amine-coated MSN at pH 5.0 and 7.4 are very different and demonstrate that electrostatic interactions between entrapped rhodamine 6G molecules and the charged surface of the MSN have a significant effect on release kinetics. Release of rhodamine 6G from amine-coated MSN can be fit to a single exponential function, while release from bare MSN can be fit to a double exponential function-indicating that the release of rhodamine 6G from bare MSN is a two-phase process. In addition, it was determined that MSN need to be sonicated in dye solution to maximize their loading capacity. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：128 / 134
页数：7
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