pH-Sensitive Clays as Drug Delivery Carriers for Controlled Release of Hydrocortisone

被引：0
|
作者：
Ghebaur, Adi [1 ]
Balanuca, Brindusa [1 ]
Garea, Sorina Alexandra [1 ]
Iovu, Horia [1 ,2 ]
机构：
[1] Univ Politehn Bucuresti, Adv Polymer Mat Grp, 1-7 Gheorghe Polizu Str, Bucharest 011061, Romania
[2] Acad Romanian Scientists, 54 Splaiul Independentei, Bucharest 50085, Romania
来源：
MATERIALE PLASTICE | 2016年 / 53卷 / 03期
关键词：
halloysite; modification; drug encapsulation; methacrylate groups; hydrocortisone; IN-VITRO RELEASE; HALLOYSITE NANOTUBES; SUSTAINED-RELEASE; ANTICANCER DRUG; NANOCOMPOSITES; METHACRYLATE); INTERCALATION; CYTOTOXICITY; COMPOSITES; IBUPROFEN;
D O I：
暂无
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The main goal of this study was to modify halloysite with polyethylene glycol methacrylate and polyethylene glycol dimethacrylate in order to realize some pH sensitive controlled drug delivery systems. The obtained samples were characterized by spectral techniques (FTIR, XPS) and thermal techniques (TGA, DSC). There was also studied the influence of clay type and initial clay amount onto the drug adsorption process within halloysite. The hydrocortisone release profile was also investigated in simulated gastric fluid and simulated intestinal fluid.
引用
收藏
页码：419 / 423
页数：5
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