A convenient, rapid microwave assisted synthesis of some novel 3-[(4-chloro-3-methylphenoxy)methyl]-6-aryl-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles using acidic alumina

被引：5

作者：

Raval, Jignesh P. ^{[1
]}

Patel, Hemul V. ^{[1
]}

Patel, Pradip S. ^{[1
]}

Desai, Kishor R. ^{[2
]}

机构：

[1] Ashok & Rita Patel Inst Integrated Study & Res Bi, Dept Pharmaceut Chem, Anand 388121, Gujarat, India

[2] Veer Narmad S Gujarat Univ, Dept Chem, Surat 395001, Gujarat, India

来源：

JOURNAL OF SAUDI CHEMICAL SOCIETY | 2010年 / 14卷 / 04期

关键词：

Microwave; Triazolo[3,4-b][1,3,4]thiadiazole; Acidic alumina; PHARMACOLOGICAL-ACTIVITIES; ANTIFUNGAL ACTIVITY; DERIVATIVES; 1,3,4-THIADIAZOLE; ANTIBACTERIAL; CHEMISTRY;

D O I：

10.1016/j.jscs.2010.05.005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile synthesis of 3-[(4-chloro-3-methylphenoxy)methyl]-6-aryl-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 3a-n has been achieved by microwave promoted condensation of 3-mercapto-4-amino-5-[(4-chloro-3-methylphenoxy)methyl]-4H-1,2,4-triazole 1 with various aromatic aldehydes 2a-n in presence of catalytic amount of p-TsOH (para-toluenesulphonic acid). The structures of 3a-n are supported by IR and H-1 and C-13, NMR spectral data. (C) 2010 King Saud University. All rights reserved.

引用

页码：417 / 421

页数：5

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