Placental expression of retinol-binding protein 4 in patients with preeclampsia

被引：0
|
作者：
Shim, E. [1 ]
Park, J. Y. [2 ]
Seol, H. J. [2 ]
机构：
[1] Kyung Hee Univ, Grad Sch, Dept Med, Seoul, South Korea
[2] Kyung Hee Univ Hosp Gangdong, Dept Obstet & Gynecol, 892 Dongnam Ro, Seoul 05278, South Korea
来源：
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY | 2018年 / 45卷 / 01期
关键词：
Retinol-binding protein 4; Placenta; Preeclampsia; GESTATIONAL DIABETES-MELLITUS; INSULIN-RESISTANCE; ONSET PREECLAMPSIA; WOMEN; DISEASE; HEALTH; RISK; METAANALYSIS; ASSOCIATION; PATTERNS;
D O I：
10.12891/ceog3783.2018
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Purpose of investigation: The aim of this study was to investigate retinol-binding protein 4 (RBP4) expression in the placenta of patients with preeclampsia and in normal pregnant women in the third trimester of pregnancy. Materials and Methods: Sixteen patients with preeclampsia and 11 normal healthy pregnant women were included. Placental RBP4 mRNA levels were quantified by real-time polymerase chain reaction (RT-PCR) and RBP4 protein expression in placental tissues was determined by western blot analysis and immunofluorescence. Results: Placental RBP4 mRNA expression was increased in patients with preeclampsia compared to normal controls. No association was observed between placental RBP4 mRNA expression and maternal body mass index or neonatal weight. Conclusion: Placental RBP4 expression was upregulated in patients with preeclampsia. This result suggested that placental RBP4 may play a role in exaggerated insulin resistance in preeclampsia.
引用
收藏
页码：98 / 101
页数：4
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