Amplification of the Signal Intensity of Fluorescence-Based Fiber-Optic Biosensors Using a Fabry-Perot Resonator Structure

被引:10
|
作者
Hsieh, Meng-Chang [1 ,2 ]
Chiu, Yi-Hsin [2 ]
Lin, Sheng-Fu [3 ]
Chang, Jenq-Yang [3 ]
Chang, Chia-Ou [1 ]
Chiang, Huihua Kenny [2 ]
机构
[1] Natl Taiwan Univ, Inst Appl Mech, Taipei 10617, Taiwan
[2] Natl Yang Ming Univ, Inst Biomed Engn, Taipei 11221, Taiwan
[3] Natl Cent Univ, Dept Opt & Photon, Jhongli 32001, Taiwan
来源
SENSORS | 2015年 / 15卷 / 02期
关键词
QUARTZ-CRYSTAL MICROBALANCE; SURFACE; NANOPARTICLES; IMMUNOASSAY;
D O I
10.3390/s150203565
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Fluorescent biosensors have been widely used in biomedical applications. To amplify the intensity of fluorescence signals, this study developed a novel structure for an evanescent wave fiber-optic biosensor by using a Fabry-Perot resonator structure. An excitation light was coupled into the optical fiber through a laser-drilled hole on the proximal end of the resonator. After entering the resonator, the excitation light was reflected back and forth inside the resonator, thereby amplifying the intensity of the light in the fiber. Subsequently, the light was used to excite the fluorescent molecules in the reactive region of the sensor. The experimental results showed that the biosensor signal was amplified eight-fold when the resonator reflector was formed using a 92% reflective coating. Furthermore, in a simulation, the biosensor signal could be amplified 20-fold by using a 99% reflector.
引用
收藏
页码:3565 / 3574
页数:10
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