Comparator-based gene regulatory network designs for control of expression

被引：1

作者：

Kazemi, J. ^{[1
]}

Ozgoli, S. ^{[1
]}

Ingalls, B. P. ^{[2
]}

机构：

[1] Tarbiat Modares Univ, Sch Elect & Comp Engn, Adv Control Syst Lab, Tehran, Iran

[2] Univ Waterloo, Dept Appl Math, Waterloo, ON N2L 3G1, Canada

来源：

IFAC PAPERSONLINE | 2018年 / 51卷 / 19期

关键词：

Synthetic Biology; Feedback Control; Relay Switch; Synthetic Genetic Comparator; ROBUST PERFECT ADAPTATION; INTEGRAL FEEDBACK-CONTROL; IMPLEMENTATION; CELLS;

D O I：

10.1016/j.ifacol.2018.09.031

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

We present comparator-based gene network designs for feedback control of the concentration of gene products. Two gene circuit designs are proposed, each of which compares concentrations of an input transcription factor (the reference input) with the protein product of a target gene (the process output). These designs employ a genetic relay switch and a shifted subtractor as components of a discrete comparator circuit and a bistable comparator circuit, respectively. Numerical simulation results illustrate the potential effectiveness of the designed controllers. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

引用

页码：38 / 41

页数：4

共 50 条

[1] A Comparator-Based Rail Clamp
Venkatasubramanian, Ramachandran
Oertle, Kent
Ozev, Sule
IEEE TRANSACTIONS ON VERY LARGE SCALE INTEGRATION (VLSI) SYSTEMS, 2016, 24 (04) : 1493 - 1502
[2] Noise Analysis for Comparator-Based Circuits
Sepke, Todd
Holloway, Peter
Sodini, Charles G.
Lee, Hae-Seung
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS, 2009, 56 (03) : 541 - 553
[3] Comparator-Based Successive Folding ADC
Chio, U-Fat
Choi, Hou-Lon
Chan, Chi-Hang
Wong, Si-Seng
Sin, Sai-Weng
U, Seng-Pan
Martins, R. P.
2009 ASIA PACIFIC CONFERENCE ON POSTGRADUATE RESEARCH IN MICROELECTRONICS AND ELECTRONICS (PRIMEASIA 2009), 2009, : 117 - 120
[4] Comparison of opamp-based and comparator-based δ-σ modulation
Momeni, Massoud
Bacinschi, Petru Bogdan
Glesner, Manfred
2008 DESIGN, AUTOMATION AND TEST IN EUROPE, VOLS 1-3, 2008, : 604 - 609
[5] Comparator-based buffer with resistive error correction
Chae, J.
Temes, G. C.
ELECTRONICS LETTERS, 2010, 46 (17) : 1188 - U36
[6] A Continuously Trimmable Comparator-based Gain Stage
Rieger, R.
Chang, L. -S.
2009 52ND IEEE INTERNATIONAL MIDWEST SYMPOSIUM ON CIRCUITS AND SYSTEMS, VOLS 1 AND 2, 2009, : 369 - 372
[7] A Linear Comparator-based Fully Digital Delay Element
Seraj, Afshin
Maymandi-Nejad, Mohammad
Bahmanyar, Parvin
Sachdev, Manoj
2015 IEEE COMPUTER SOCIETY ANNUAL SYMPOSIUM ON VLSI, 2015, : 652 - 655
[8] A COMPARATOR-BASED SWITCHED-CAPACITOR INTEGRATOR USING A NEW CHARGE CONTROL CIRCUIT
Parsan, Farhad Alibeygi
Ayatollahi, Ahmad
IEEE INTERNATIONAL SOC CONFERENCE, PROCEEDINGS, 2008, : 139 - 142
[9] Validation of a Blackbody Comparator-Based System for Thermocouple Calibration
M. Ojanen
O. Hahtela
M. Heinonen
International Journal of Thermophysics, 2014, 35 : 526 - 534
[10] EMPIRICAL COMPLEXITY OF COMPARATOR-BASED NEAREST NEIGHBOR DESCENT
Baron, Jacob D.
Darling, R.W.R.
arXiv, 2022,

← 1 2 3 4 5 →