Synthetic inhibitors of yeast cyclin-dependent kinase-activating kinases as antifungal agents

被引：0
|
作者：
不详
机构：
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2003年 / 13卷 / 06期
关键词：
antifungal; cyclin-dependent kinase (CDK); cyclin-dependent kinase-activating kinase (CAK); indolizines; kinase inhibitors;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The Vertex application discloses an indeterminate number of indolizine and related heterocyclic derivatives that are claimed to be inhibitors of cyclin-dependent kinase (CDK)-activating kinases (CAKs), useful as antifungal agents. The GPC Biotech application discloses an, indeterminate number of compounds with a phenethylazaryl 'portion' linked to various substituents; all claimed to be inhibitors of various fungal enzymes, particularly prenyltransferases and CAK.
引用
收藏
页码：925 / 927
页数：3
相关论文
共 50 条
  • [41] Inhibitors of cyclin-dependent kinases as cancer therapeutics
    Whittaker, Steven R.
    Mallinger, Aurelie
    Workman, Paul
    Clarke, Paul A.
    PHARMACOLOGY & THERAPEUTICS, 2017, 173 : 83 - 105
  • [42] Small molecules as inhibitors of cyclin-dependent kinases
    Huwe, A
    Mazitschek, R
    Giannis, A
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (19) : 2122 - 2138
  • [43] β-Carbolines as specific inhibitors of cyclin-dependent kinases
    Song, YC
    Wang, J
    Teng, SF
    Kesuma, D
    Deng, Y
    Duan, JN
    Wang, JH
    Qi, RZ
    Sim, MM
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (07) : 1129 - 1132
  • [44] Cyclin-dependent kinase inhibitors in yeast, animals, and plants:: A functional comparison
    De Clercq, Annelies
    Inze, Dirk
    CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2006, 41 (05) : 293 - 313
  • [45] Overexpression of cyclin-dependent kinase-activating CDC25B phosphatase in human gastric carcinomas
    Kudo, Y
    Yasui, W
    Ue, T
    Yamamoto, S
    Yokozaki, H
    Nikai, H
    Tahara, E
    JAPANESE JOURNAL OF CANCER RESEARCH, 1997, 88 (10): : 947 - 952
  • [46] Cyclin-dependent kinases inhibitors as potential anticancer, antineurodegenerative, antiviral and antiparasitic agents
    Meijer, L
    DRUG RESISTANCE UPDATES, 2000, 3 (02) : 83 - 88
  • [47] Novel cyclin-dependent kinase inhibitors
    Westwell, AD
    DRUG DISCOVERY TODAY, 2001, 6 (13) : 701 - 701
  • [48] INHIBITORS OF CYCLIN-DEPENDENT KINASE AND CANCER
    BIGGS, JR
    KRAFT, AS
    JOURNAL OF MOLECULAR MEDICINE-JMM, 1995, 73 (10): : 509 - 514
  • [49] Hepatitis C virus core functions as a suppressor of cyclin-dependent kinase-activating kinase and impairs cell cycle progression
    Ohkawa, K
    Ishida, H
    Nakanishi, F
    Hosui, A
    Ueda, K
    Takehara, T
    Hori, M
    Hayashi, N
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (12) : 11719 - 11726
  • [50] Cyclin-dependent kinase inhibitors and hepatocarcinogenesis
    Hui, AM
    Sakamoto, M
    Kanai, Y
    Ino, Y
    Gotoh, M
    Hirohashi, S
    RECENT ADVANCES IN GASTROENTEROLOGICAL CARCINOGENESIS I, 1996, : 481 - 485
12345