Biological features of the clone involved in primary amyloidosis (AL)

被引：12
|
作者：
Perfetti, V
Vignarelli, MC
Casarini, S
Ascari, E
Merlini, G
机构：
[1] Univ Pavia, Dept Internal Med, I-27100 Pavia, Italy
[2] Univ Pavia, IRCCS, Policlin S Matteo, Biotechnol Res Labs, I-27100 Pavia, Italy
来源：
LEUKEMIA | 2001年 / 15卷 / 02期
关键词：
primary amyloidosis; AL amyloidosis; plasma cell dyscrasias; B cell lymphoproliferative disorders;
D O I：
10.1038/sj.leu.2402015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Primary light chain-associated amyloidosis (AL) is a plasma cell dyscrasia that causes morbidity via systemic tissue deposition of monoclonal light chains in the form of fibrils (amyloid). It is the most common form of systemic amyloidosis in Western countries and is rapidly fatal. Knowledge of the pathobiology of the underlying B cell clone is of primary importance for the design and optimization of therapeutic strategies.
引用
收藏
页码：195 / 202
页数：8
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