Biological features of the clone involved in primary amyloidosis (AL)

被引：12
|
作者：
Perfetti, V
Vignarelli, MC
Casarini, S
Ascari, E
Merlini, G
机构：
[1] Univ Pavia, Dept Internal Med, I-27100 Pavia, Italy
[2] Univ Pavia, IRCCS, Policlin S Matteo, Biotechnol Res Labs, I-27100 Pavia, Italy
来源：
LEUKEMIA | 2001年 / 15卷 / 02期
关键词：
primary amyloidosis; AL amyloidosis; plasma cell dyscrasias; B cell lymphoproliferative disorders;
D O I：
10.1038/sj.leu.2402015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Primary light chain-associated amyloidosis (AL) is a plasma cell dyscrasia that causes morbidity via systemic tissue deposition of monoclonal light chains in the form of fibrils (amyloid). It is the most common form of systemic amyloidosis in Western countries and is rapidly fatal. Knowledge of the pathobiology of the underlying B cell clone is of primary importance for the design and optimization of therapeutic strategies.
引用
收藏
页码：195 / 202
页数：8
相关论文
共 50 条
  • [21] Hepatic Amyloidosis Due to Primary AL Amyloidosis Presenting as Recurrent Ascites
    Patel, Roohi
    Law, Cindy S.
    Ali, Mahmoud
    Patel, Anish V.
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2021, 116 : S1188 - S1188
  • [22] Treatment in AL Amyloidosis: Moving towards Individualized and Clone-Directed Therapy
    Hegenbart, Ute
    Raab, Marc S.
    Schoenland, Stefan O.
    HEMATO, 2021, 2 (04): : 739 - 747
  • [23] Hepatic failure due to primary AL amyloidosis
    Varela, M
    De las Heras, D
    Miquel, R
    JOURNAL OF HEPATOLOGY, 2003, 39 (02) : 290 - 290
  • [24] Restrictive cardiomyopathy due to primary amyloidosis AL
    Ruckert, Y
    Hansen, A
    Dorffel, WV
    Eckert, B
    Scholze, J
    ZEITSCHRIFT FUR KARDIOLOGIE, 1997, 86 (10): : 812 - 817
  • [25] Primary (AL) amyloidosis in plasma cell disorders
    Mueller, Antonia M. S.
    Geibel, Annette
    Neumann, Hartmut P. H.
    Kuehnemund, Alexander
    Schmitt-Graeff, Annette
    Boehm, Joachim
    Engelhardt, Monika
    ONCOLOGIST, 2006, 11 (07): : 824 - 830
  • [26] Therapy and management of systemic AL (primary) amyloidosis
    Palladini, Giovanni
    Perfetti, Vittorio
    Merlini, Giampaolo
    SWISS MEDICAL WEEKLY, 2006, 136 (45-46) : 715 - 720
  • [27] Primary amyloidosis (AL) as a cause of nephrotic syndrome
    Bataille, Y
    Bovy, C
    Lancellotti, P
    Melchior, V
    Delbecque, K
    Beguin, Y
    Krzesinski, JM
    ACTA CLINICA BELGICA, 2005, 60 (02) : 94 - 97
  • [28] Symptomatic Primary (AL) Amyloidosis of the Stomach and Duodenum
    Fossmark, Reidar
    Skarsvag, Espen
    Aarset, Harald
    Hjorth-Hansen, Henrik
    Waldum, Helge L.
    CASE REPORTS IN GASTROINTESTINAL MEDICINE, 2013, 2013
  • [29] PRIMARY (AL) AMYLOIDOSIS AS A CAUSE OF BREAST MASSES
    OCONNOR, CR
    RUBINOW, A
    COHEN, AS
    AMERICAN JOURNAL OF MEDICINE, 1984, 77 (06): : 981 - 986
  • [30] Therapeutic strategies in primary AL-amyloidosis
    Sezer, O
    Eucker, J
    Heider, U
    Rothermundt, C
    Schmid, P
    Schweigert, M
    Possinger, K
    BONE MARROW TRANSPLANTATION, 1999, 23 : S8 - S9
12345