Screening in veterinary drug analysis and sports doping control based on full-scan, accurate-mass spectrometry

被引：74
|
作者：
Peters, R. J. B. [1 ]
Stolker, A. A. M. [1 ]
Mol, J. G. J. [1 ]
Lommen, A. [1 ]
Lyris, E. [1 ,2 ]
Angelis, Y. [1 ,2 ]
Vonaparti, A. [1 ,2 ]
Stamou, M. [1 ,2 ]
Georgakopoulos, C. [1 ,2 ]
Nielen, M. W. F. [1 ,3 ]
机构：
[1] Inst Food Safety, RIKILT, NL-6700 AE Wageningen, Netherlands
[2] Olymp Athlet Ctr Athens, Doping Control Lab Athens, Athens 15123, Greece
[3] Wageningen Univ, Organ Chem Lab, NL-6703 HB Wageningen, Netherlands
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2010年 / 29卷 / 11期
关键词：
Chromatography; Food contaminant; Mass spectrometry (MS); Metabolite; Orbitrap; Prohibited substance; Sports doping; Time of flight (TOF); Unified screening; Veterinary drug; HORSE URINE ANALYSIS; GC-TOF MS; LIQUID-CHROMATOGRAPHY; GAS-CHROMATOGRAPHY; RESIDUE ANALYSIS; METABOLITE IDENTIFICATION; THRESHOLD SUBSTANCES; ORGANIC POLLUTANTS; UNKNOWN PESTICIDES; UPLC-TOF;
D O I：
10.1016/j.trac.2010.07.012
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A common trend in food contaminants and sports doping control is towards a limited number of targeted, full-scan, accurate-mass spectrometry (MS) methods based on time-of-flight (TOF) or Fourier-transform orbital trap (Orbitrap) mass analyzers. Retrospective analysis of the full-scan datasets of signals from emerging contaminants, novel metabolites and illegal designer substances is a major step forward. We present data from recent applications of gas chromatography with TOF-MS, ultra-high-performance liquid chromatography (LC) with TOE-MS and LC-Orbitrap MS in the screening of European Commission-regulated veterinary drugs and other contaminants in foods, and World Anti-Doping Agency-prohibited substances. We discuss the potential impact of these new approaches on future developments. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1250 / 1268
页数：19
相关论文
共 44 条
  • [41] Electrostatic Spray Ionization from 384-Well Microtiter Plates for Mass Spectrometry Analysis-Based Enzyme Assay and Drug Metabolism Screening
    Qiao, Liang
    Zhong, Xiaoqin
    Belghith, Emna
    Deng, Yan
    Lin, Tzu-En
    Tobolkina, Elena
    Liu, Baohong
    Girault, Hubert H.
    [J]. ANALYTICAL CHEMISTRY, 2017, 89 (11) : 5984 - 5991
  • [42] Liquid chromatography-full scan-high resolution mass spectrometry-based method towards the comprehensive analysis of migration of primary aromatic amines from food packaging
    Mattarozzi, Monica
    Lambertini, Francesca
    Suman, Michele
    Careri, Maria
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2013, 1320 : 96 - 102
  • [43] Preventive doping control screening analysis of prohibited substances in human urine using rapid-resolution liquid chromatography/high-resolution time-of-flight mass spectrometry
    Vonaparti, A.
    Lyris, E.
    Angelis, Y. S.
    Panderi, I.
    Koupparis, M.
    Tsantili-Kakoulidou, A.
    Peters, R. J. B.
    Nielen, M. W. F.
    Georgakopoulos, C.
    [J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2010, 24 (11) : 1595 - 1609
  • [44] Rapid and Semiautomated Method for the Analysis of Veterinary Drug Residues in Honey Based on Turbulent-Flow Liquid Chromatography Coupled to Ultrahigh-Performance Liquid Chromatography-Orbitrap Mass Spectrometry (TFC-UHPLC-Orbitrap-MS)
    Aguilera-Luiz, Maria M.
    Romero-Gonzalez, Roberto
    Plaza-Bolanos, Patricia
    Martinez Vidal, Jose L.
    Garrido Frenich, Antonia
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2013, 61 (04) : 829 - 839
12345