Screening in veterinary drug analysis and sports doping control based on full-scan, accurate-mass spectrometry

被引：74
|
作者：
Peters, R. J. B. [1 ]
Stolker, A. A. M. [1 ]
Mol, J. G. J. [1 ]
Lommen, A. [1 ]
Lyris, E. [1 ,2 ]
Angelis, Y. [1 ,2 ]
Vonaparti, A. [1 ,2 ]
Stamou, M. [1 ,2 ]
Georgakopoulos, C. [1 ,2 ]
Nielen, M. W. F. [1 ,3 ]
机构：
[1] Inst Food Safety, RIKILT, NL-6700 AE Wageningen, Netherlands
[2] Olymp Athlet Ctr Athens, Doping Control Lab Athens, Athens 15123, Greece
[3] Wageningen Univ, Organ Chem Lab, NL-6703 HB Wageningen, Netherlands
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2010年 / 29卷 / 11期
关键词：
Chromatography; Food contaminant; Mass spectrometry (MS); Metabolite; Orbitrap; Prohibited substance; Sports doping; Time of flight (TOF); Unified screening; Veterinary drug; HORSE URINE ANALYSIS; GC-TOF MS; LIQUID-CHROMATOGRAPHY; GAS-CHROMATOGRAPHY; RESIDUE ANALYSIS; METABOLITE IDENTIFICATION; THRESHOLD SUBSTANCES; ORGANIC POLLUTANTS; UNKNOWN PESTICIDES; UPLC-TOF;
D O I：
10.1016/j.trac.2010.07.012
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A common trend in food contaminants and sports doping control is towards a limited number of targeted, full-scan, accurate-mass spectrometry (MS) methods based on time-of-flight (TOF) or Fourier-transform orbital trap (Orbitrap) mass analyzers. Retrospective analysis of the full-scan datasets of signals from emerging contaminants, novel metabolites and illegal designer substances is a major step forward. We present data from recent applications of gas chromatography with TOF-MS, ultra-high-performance liquid chromatography (LC) with TOE-MS and LC-Orbitrap MS in the screening of European Commission-regulated veterinary drugs and other contaminants in foods, and World Anti-Doping Agency-prohibited substances. We discuss the potential impact of these new approaches on future developments. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1250 / 1268
页数：19
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