Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice

被引：18
|
作者：
Zhang, Xiaoying
Kundoor, Vipra
Khalifa, Sherief
Zeman, David
Fahmy, Hesham
Dwivedi, Chandradhar
机构：
[1] S Dakota State Univ, Coll Pharm, Dept Pharmaceut Sci, Brookings, SD 57007 USA
[2] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia, Egypt
[3] S Dakota State Univ, Dept Vet Sci, Brookings, SD 57007 USA
来源：
CANCER LETTERS | 2007年 / 253卷 / 01期
关键词：
chemoprevention; sarcophine-diol; apoptosis; cyclooxygenase-2 (COX-2); skin cancer;
D O I：
10.1016/j.canlet.2007.01.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The objective of this study was to determine the chemopreventive effects of sarcophine-diol (SD) on 7,12-dimethylbenz(a)anthracene initiated and 12-O-tetradecanoylphorbol-13-acetate promoted skin tumor development in mice and its possible mechanisms of action. SD pretreatment significantly (P < 0.05) decreased skin papilloma development during promotion phase. SD significantly (P < 0.05) increased caspase-3 and decreased cyclooxygenase-2 during initiation phase or promotion phase. SD significantly (P < 0.05) increased caspase-8 during promotion phase. SD resulted in a 95% reduction in 12-O-tetradecanoylphorbol-13-acetate-induced DNA synthesis. SD could be an effective chemopreventive agent for skin cancer by enhancing apoptosis and decreasing cell proliferation. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：53 / 59
页数：7
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