Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice

被引：18

作者：

Zhang, Xiaoying

Kundoor, Vipra

Khalifa, Sherief

Zeman, David

Fahmy, Hesham

Dwivedi, Chandradhar

机构：

[1] S Dakota State Univ, Coll Pharm, Dept Pharmaceut Sci, Brookings, SD 57007 USA

[2] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia, Egypt

[3] S Dakota State Univ, Dept Vet Sci, Brookings, SD 57007 USA

来源：

CANCER LETTERS | 2007年 / 253卷 / 01期

关键词：

chemoprevention; sarcophine-diol; apoptosis; cyclooxygenase-2 (COX-2); skin cancer;

D O I：

10.1016/j.canlet.2007.01.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The objective of this study was to determine the chemopreventive effects of sarcophine-diol (SD) on 7,12-dimethylbenz(a)anthracene initiated and 12-O-tetradecanoylphorbol-13-acetate promoted skin tumor development in mice and its possible mechanisms of action. SD pretreatment significantly (P < 0.05) decreased skin papilloma development during promotion phase. SD significantly (P < 0.05) increased caspase-3 and decreased cyclooxygenase-2 during initiation phase or promotion phase. SD significantly (P < 0.05) increased caspase-8 during promotion phase. SD resulted in a 95% reduction in 12-O-tetradecanoylphorbol-13-acetate-induced DNA synthesis. SD could be an effective chemopreventive agent for skin cancer by enhancing apoptosis and decreasing cell proliferation. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：53 / 59

页数：7

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