Gene Modified T Cell Therapies for Hematological Malignancies

被引：5
|
作者：
Abramowski-Mock, Ulrike [1 ]
Delhove, Juliette M. [1 ]
Qasim, Waseem [1 ]
机构：
[1] UCL, Mol & Cellular Immunol Unit, UCL Great Ormond St Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2017年 / 31卷 / 05期
基金：
“创新英国”项目;
关键词：
Gene therapy; Gene editing; Adoptive immunotherapy; T cell receptor; Chimeric antigen receptor; Lentiviral vectors; Leukemia; Lymphoma; CHIMERIC-ANTIGEN-RECEPTOR; ACUTE MYELOID-LEUKEMIA; ZINC-FINGER NUCLEASES; B-CELL; CANCER-IMMUNOTHERAPY; ADOPTIVE IMMUNOTHERAPY; IMMUNE CHECKPOINTS; MULTIPLE-MYELOMA; CLINICAL-TRIAL; LYMPHOCYTES;
D O I：
10.1016/j.hoc.2017.06.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This article focuses on clinical applications of T cells transduced to express recombinant T-cell receptor and chimeric antigen receptor constructs directed toward hematological malignancies, and considers newer strategies incorporating gene-editing technologies to address graft-versus-host disease and host-mediated rejection. Recent data from clinical trials are reviewed, and an overview is provided of current and emerging manufacturing processes; consideration is also given to new developments in the pipeline.
引用
收藏
页码：913 / +
页数：15
相关论文
共 50 条
  • [31] Apoptosis-based therapies for hematological malignancies
    Petronelli, A
    Riccioni, R
    Pasquini, L
    Petrucci, E
    Testa, U
    DRUGS OF THE FUTURE, 2005, 30 (07) : 707 - 723
  • [32] Immune-based Therapies for Hematological Malignancies: An Update by the EHA SWG on Immunotherapy of Hematological Malignancies
    Einsele, Hermann
    Briones, Javier
    Ciceri, Fabio
    Garcia-Cadenas, Irene
    Falkenburg, Fred
    Bolanos, Natacha
    Heemskerk, H. M. Mirjam
    Houot, Roch
    Hudecek, Michael
    Locatelli, Franco
    Morgan, Kate
    Morris, C. Emma
    O'Dwyer, Michael
    Gil, Jordi Sierra
    van den Brink, Marcel
    van de Loosdrecht, Arjan A.
    HEMASPHERE, 2020, 4 (04):
  • [33] Gene therapy for hematological malignancies
    Schmidt-Wolf, GD
    Schmidt-Wolf, IGH
    CLINICAL AND EXPERIMENTAL MEDICINE, 2003, 3 (01) : 4 - 14
  • [34] Gene and virotherapy for hematological malignancies
    Domingo-Musibay, Evidio
    Yamamoto, Masato
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2016, 104 (01) : 29 - 41
  • [35] Gene and virotherapy for hematological malignancies
    Evidio Domingo-Musibay
    Masato Yamamoto
    International Journal of Hematology, 2016, 104 : 29 - 41
  • [36] Gene therapy for hematological malignancies
    G.D. Schmidt-Wolf
    I.G.H. Schmidt-Wolf
    Clinical and Experimental Medicine, 2003, 3 : 4 - 14
  • [37] Impact of T cell characteristics on CAR-T cell therapy in hematological malignancies
    Tao, Zhongfei
    Chyra, Zuzana
    Kotulova, Jana
    Celichowski, Piotr
    Mihalyova, Jana
    Charvatova, Sandra
    Hajek, Roman
    BLOOD CANCER JOURNAL, 2024, 14 (01):
  • [38] ASSOCIATION OF NATURAL KILLER CELL KIR GENE WITH HEMATOLOGICAL MALIGNANCIES
    Khamaganova, Ekaterina G.
    Suchkova, Marina V.
    HUMAN IMMUNOLOGY, 2011, 72 : S138 - S138
  • [39] Chimeric antigen T cell receptor treatment in hematological malignancies
    Ali, Natasha
    BLOOD RESEARCH, 2019, 54 (02) : 81 - 83
  • [40] Novel Targeted Therapies for T-Cell Malignancies
    Tesio, Melania
    CANCERS, 2022, 14 (16)
12345