Gene Modified T Cell Therapies for Hematological Malignancies

被引：5

作者：

Abramowski-Mock, Ulrike ^{[1
]}

Delhove, Juliette M. ^{[1
]}

Qasim, Waseem ^{[1
]}

机构：

[1] UCL, Mol & Cellular Immunol Unit, UCL Great Ormond St Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2017年 / 31卷 / 05期

基金：

“创新英国”项目;

关键词：

Gene therapy; Gene editing; Adoptive immunotherapy; T cell receptor; Chimeric antigen receptor; Lentiviral vectors; Leukemia; Lymphoma; CHIMERIC-ANTIGEN-RECEPTOR; ACUTE MYELOID-LEUKEMIA; ZINC-FINGER NUCLEASES; B-CELL; CANCER-IMMUNOTHERAPY; ADOPTIVE IMMUNOTHERAPY; IMMUNE CHECKPOINTS; MULTIPLE-MYELOMA; CLINICAL-TRIAL; LYMPHOCYTES;

D O I：

10.1016/j.hoc.2017.06.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This article focuses on clinical applications of T cells transduced to express recombinant T-cell receptor and chimeric antigen receptor constructs directed toward hematological malignancies, and considers newer strategies incorporating gene-editing technologies to address graft-versus-host disease and host-mediated rejection. Recent data from clinical trials are reviewed, and an overview is provided of current and emerging manufacturing processes; consideration is also given to new developments in the pipeline.

引用

页码：913 / +

页数：15

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