On the structural basis of peptide-bond formation and antibiotic resistance from atomic structures of the large ribosomal subunit

被引：26

作者：

Steitz, TA

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

[2] Howard Hughes Med Inst, New Haven, CT 06520 USA

来源：

FEBS LETTERS | 2005年 / 579卷 / 04期

关键词：

ribosome structure; antibiotics; RNA structure; ribozyme; peptidyl transferase mechanism;

D O I：

10.1016/j.febslet.2004.11.053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The atomic structures of the large ribosomal subunit from Haloarcula marismortui and its complexes with substrates and antibiotics have provided insights into the way the 3000 nucleotide 23S rRNA folds into a compact, specific structure and interacts with 27 ribosomal proteins as well as the structural basis of the peptidyl transferase reaction and its inhibition by antibiotics. The structure shows that the ribosome is indeed a ribozvme. (C) 2064 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：955 / 958

页数：4

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