Polyhydroxylated steroids from the soft coral Sinularia dissecta

被引：26

作者：

Jin, PF

Deng, ZW

Pei, YH

Fu, HZ

Li, J

Van Ofwegen, LP

Proksch, P

Lin, WH ^{[1
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

[2] Shenyang Pharmaceut Univ, Tradit Chines Med Coll, Shenyang 110016, Peoples R China

[3] Beijing Normal Univ, Analyt & Testing Ctr, Beijing 100073, Peoples R China

[4] Natl Univ Natl Hist Nat, NL-2300 RA Leiden, Netherlands

[5] Univ Dusseldorf, Inst Pharmaceut Biol, D-40225 Dusseldorf, Germany

来源：

STEROIDS | 2005年 / 70卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Sinularia dissecta; poiyhydroxylated steroids; dissectolide;

D O I：

10.1016/j.steroids.2005.01.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A repeated silica gel column chromatography followed by HPLC purification on the methanol extract of marine soft coral Sinularia dissecta, resulted in the isolation of fifteen polyhydroxylated steroids (1-15), involving six new C- 18 functionalized steroids, 3 beta-acetoxy-1 alpha, 11 alpha-dihydroxygorgost-5-en- 18-oic acid (1), gorgost-5-en-1 alpha,3 beta,11 alpha, 18-tetrol (2), 18-acetoxy-1 alpha,3 beta, 11 alpha-trihydroxygorgost-5-ene (3), 24(S)-3 beta-acetoxy- 1 alpha, 11 alpha-dihydroxyergost-5-en- 18-oic acid (4), 24(S)-ergost-5-en- 1 alpha,3 beta, 11 alpha, 18-tetrol (5), and dissectolide (6). The structures of the new compounds were determined on the basis of extensive spectroscopic data (IR. MS, (1)H and (13)C NMR, HMQC, HMBC, and NOESY) analysis. Compound 6 was found as an unusual sterol bearing a lactone functionality. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：487 / 493

页数：7

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