Combinatorial assembly of neurons: from chromatin to dendrites

被引：4
|
作者：
de la Torre-Ubieta, Luis [1 ,2 ]
Bonni, Azad [1 ,2 ]
机构：
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA
来源：
TRENDS IN CELL BIOLOGY | 2008年 / 18卷 / 02期
关键词：
D O I：
10.1016/j.tcb.2007.12.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The generation and refinement of dendrites is essential for normal brain development and function. However, the molecular mechanisms that govern dendritic morphogenesis are poorly understood. Recent studies from the Crabtree laboratory have uncovered a requirement for the neuron-specific chromatin-remodeling enzyme nBAF in dendritic growth and branching in response to neuronal activity. These findings highlight the significance of epigenetic mechanisms in activity-dependent dendritic morphogenesis, with important implications in brain development and plasticity.
引用
收藏
页码：48 / 51
页数：4
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