Combinatorial assembly of neurons: from chromatin to dendrites

被引:4
|
作者
de la Torre-Ubieta, Luis [1 ,2 ]
Bonni, Azad [1 ,2 ]
机构
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA
关键词
D O I
10.1016/j.tcb.2007.12.003
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The generation and refinement of dendrites is essential for normal brain development and function. However, the molecular mechanisms that govern dendritic morphogenesis are poorly understood. Recent studies from the Crabtree laboratory have uncovered a requirement for the neuron-specific chromatin-remodeling enzyme nBAF in dendritic growth and branching in response to neuronal activity. These findings highlight the significance of epigenetic mechanisms in activity-dependent dendritic morphogenesis, with important implications in brain development and plasticity.
引用
收藏
页码:48 / 51
页数:4
相关论文
共 50 条
  • [21] Dendrites of medial olivocochlear neurons in mouse
    Brown, M. C.
    Levine, J. L.
    NEUROSCIENCE, 2008, 154 (01) : 147 - 159
  • [22] Postreplicative chromatin assembly by Drosophila and human chromatin assembly factor 1
    Kamakaka, RT
    Bulger, M
    Kaufman, PD
    Stillman, B
    Kadonaga, JT
    MOLECULAR AND CELLULAR BIOLOGY, 1996, 16 (03) : 810 - 817
  • [23] Chromatin assembly at kinetochores is uncoupled from DNA replication
    Shelby, RD
    Monier, K
    Sullivan, KF
    JOURNAL OF CELL BIOLOGY, 2000, 151 (05): : 1113 - 1118
  • [24] Differential modes of EDNF secretion from axons and dendrites of cultured hippocampal neurons
    Matsuda, Naoto
    Poo, Mu-ming
    NEUROSCIENCE RESEARCH, 2008, 61 : S47 - S47
  • [25] Chromatin assembly and organization
    Ridgway, P
    Almouzni, G
    JOURNAL OF CELL SCIENCE, 2001, 114 (15) : 2711 - 2712
  • [26] Regulating chromatin assembly
    Carim, Sabrya
    NATURE CELL BIOLOGY, 2024, 26 (12) : 2013 - 2013
  • [27] Chromatin Assembly and Disassembly
    Tyler, Jessica
    FASEB JOURNAL, 2013, 27
  • [28] ASSEMBLY OF ACTIVE CHROMATIN
    KUMAR, S
    LEFFAK, M
    FEDERATION PROCEEDINGS, 1985, 44 (03) : 870 - 870
  • [29] ASSEMBLY OF ACTIVE CHROMATIN
    KUMAR, S
    LEFFAK, M
    BIOCHEMISTRY, 1986, 25 (08) : 2055 - 2060
  • [30] Fast optical recordings of membrane potential changes from dendrites of pyramidal neurons
    Antic, S
    Major, G
    Zecevic, D
    JOURNAL OF NEUROPHYSIOLOGY, 1999, 82 (03) : 1615 - 1621