A rapid and high-throughput quantum dots bioassay for monitoring of perfluorooctane sulfonate in environmental water samples

被引：34
|
作者：
Zhang, Jiong [1 ]
Wan, Yanjian [1 ]
Li, Yuanyuan [1 ]
Zhang, Qiongfang [1 ]
Xu, Shunqing [1 ]
Zhu, Huijun [2 ]
Shu, Baihua [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan 430030, Hubei Province, Peoples R China
[2] Cranfield Univ, Kempston MK43 0AL, Beds, England
来源：
ENVIRONMENTAL POLLUTION | 2011年 / 159卷 / 05期
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
High-throughput; Monitoring; Quantum dots bioassay; Perfluorooctane sulfonate; PERFLUORINATED COMPOUNDS; REVERSE-OSMOSIS; WASTE-WATER; HUMAN BLOOD; CHINA; PFOS; FLUOROCHEMICALS; NANOPARTICLES; MEMBRANES; BINDING;
D O I：
10.1016/j.envpol.2011.01.011
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Currently HPLC/MS is the state of the art tool for environmental/drinking water perfluorooctane sulfonate (PFOS) monitoring. PFOS can bind to peroxisomal proliferator-activated receptor-alpha (PPAR alpha), which forms heterodimers with retinoid X receptors (RXRs) and binds to PPAR response elements. In this bioassay free PFOS in water samples competes with immobilized PFOS in ELISA plates for a given amount of PPAR alpha-RXR alpha. It can be determined indirectly by immobilizing PPAR alpha-RXR alpha-PFOS complex to another plate coated with PPAR alpha antibody and subsequent measuring the level of PPAR alpha-RXR alpha by using biotin-modified PPAR alpha-RXR alpha probes-quantum dots-streptavidin detection system. The rapid and high-throughput bioassay demonstrated a detection limit of 2.5 ng L(-1) with linear range between 2.5 ng L(-1) and 75 ng L(-1). Detection results of environmental water samples were highly consistent between the bioassay and HPLC/MS. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1348 / 1353
页数：6
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