Flattening filter free VMAT for a stereotactic, single-dose of 30 Gy to lung lesion in a 15-min treatment slot

被引：13
|
作者：
Pokhrel, Damodar [1 ]
Sanford, Lana [1 ]
Dhanireddy, Bhaswanth [1 ]
Molloy, Janelle [1 ]
Randall, Marcus [1 ]
McGarry, Ronald C. [1 ]
机构：
[1] Univ Kentucky, Med Phys Grad Program, Dept Radiat Med, Lexington, KY 40506 USA
来源：
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS | 2020年 / 21卷 / 04期
关键词：
beam-on time; FFF-beam; outcomes; single dose; stereotactic lung treatment; VMAT; BODY RADIATION-THERAPY; MODULATED ARC THERAPY; FREE BEAMS; RADIOTHERAPY; CANCER; FRACTION; SBRT; REGIMENS; QUALITY; TUMORS;
D O I：
10.1002/acm2.12829
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Cone-beam CT-guided single dose of lung stereotactic body radiotherapy (SBRT) treatment with a flattening filter free (FFF) beam and volumetric modulated arc therapy (VMAT) is a safe and highly effective treatment modality for selective small lung lesions. Four-dimensional (4D) CT-based treatment plans were generated using advanced AcurosXB algorithm for heterogeneity corrections. 6X-FFF beam produced highly conformal radiosurgical dose distribution to the target and reduced lung SBRT fraction duration to less than 10 min for a single dose of 30 Gy, significantly improving patient comfort and clinic workflow. Early follow-up CT imaging results (mean, 8 months) show high local control rates (100%) with no acute lung or rib toxicity. Longer clinical follow-up in a larger patient cohort managed in this fashion is underway to further validate this treatment approach.
引用
收藏
页码：6 / 12
页数：7
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