Cancer - Awakening angels

被引：52
|
作者：
Lane, D [1 ]
机构：
[1] Univ Dundee, Dept Biochem, Canc Res Campaign Labs, Dundee DD1 4HN, Scotland
来源：
NATURE | 1998年 / 394卷 / 6694期
关键词：
D O I：
10.1038/29166
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
When mammalian cells are under stress they activate the tumour-suppressor gene p53. But how does the cell signal to p53 that it is under attack? A new study implicates the DNA-dependent protein kinase (DNA-PK), which is activated by DNA damage and can bind p53. Damaged cells that don't contain DNA-PK accumulate an inactive form of p53, indicating that DNA-PK is crucial for the activation of p53.
引用
收藏
页码：616 / 617
页数：2
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