Cancer - Awakening angels

被引：52
|
作者：
Lane, D [1 ]
机构：
[1] Univ Dundee, Dept Biochem, Canc Res Campaign Labs, Dundee DD1 4HN, Scotland
来源：
NATURE | 1998年 / 394卷 / 6694期
关键词：
D O I：
10.1038/29166
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
When mammalian cells are under stress they activate the tumour-suppressor gene p53. But how does the cell signal to p53 that it is under attack? A new study implicates the DNA-dependent protein kinase (DNA-PK), which is activated by DNA damage and can bind p53. Damaged cells that don't contain DNA-PK accumulate an inactive form of p53, indicating that DNA-PK is crucial for the activation of p53.
引用
收藏
页码：616 / 617
页数：2
相关论文
共 50 条
  • [21] Awakening salivary cortisol response in women cancer survivors
    Gooney, M.
    Lane, P.
    Murphy, L.
    PSYCHO-ONCOLOGY, 2007, 16 (09) : S184 - S185
  • [22] The awakening of an advanced malignant cancer: An insult to the mitochondrial genome
    Cook, Cody C.
    Higuchi, Masahiro
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2012, 1820 (05): : 652 - 662
  • [23] Cancer treatments as paradoxical catalysts of tumor awakening in the lung
    Nicolas, Emmanuelle
    Kosmider, Beata
    Cukierman, Edna
    Borghaei, Hossein
    Golemis, Erica A.
    Borriello, Lucia
    CANCER AND METASTASIS REVIEWS, 2024, 43 (04) : 1165 - 1183
  • [24] Awakening immunity against cancer: a 2017 primer for clinicians
    Jain, Amit
    Zhang, Qing
    Toh, Han-Chong
    CHINESE JOURNAL OF CANCER, 2017, 36
  • [25] Mechanisms of disseminated cancer cell dormancy: an awakening field
    María Soledad Sosa
    Paloma Bragado
    Julio A. Aguirre-Ghiso
    Nature Reviews Cancer, 2014, 14 : 611 - 622
  • [26] Metastasis Awakening: The challenges of targeting minimal residual cancer
    Bernhard Polzer
    Christoph A Klein
    Nature Medicine, 2013, 19 : 274 - 275
  • [27] A FRESH AWAKENING + RELIGIOUS AWAKENING
    DYKSTRA, C
    THEOLOGY TODAY, 1989, 46 (02) : 125 - 128
  • [28] The Awakening of Heroine Edna in Awakening
    Liang Yuan
    PROCEEDINGS OF 2016 INTERNATIONAL SYMPOSIUM - FEMALE SURVIVAL AND DEVELOPMENT, 2016, : 3 - 7
  • [29] PROUST ANGELS, GUARDS AND GUARDIAN ANGELS
    MCLENDON, WL
    CLAUDEL STUDIES, 1990, 17 (02): : 38 - 49
  • [30] ANGELS AND NON-ANGELS - ARE THERE DIFFERENCES
    FREEAR, J
    SOHL, JE
    WETZEL, WE
    JOURNAL OF BUSINESS VENTURING, 1994, 9 (02) : 109 - 123
12345