How activity-dependent synaptic plasticity shapes the development of inhibitory synapses has remained unclear. In this issue, Gillespie et al. show that in the developing rat auditory system, inhibitory synapses transiently co-release glutamate. The consequent activation of postsynaptic NMDA receptors may be critical for the plasticity mechanisms that determine tonotopic sharpening.
机构:
Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USARockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA
Heller, Elizabeth A.
Zhang, Wenzhu
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机构:
Rockefeller Univ, Lab Mass Spectrometry & Gaseous Ion Chem, New York, NY 10021 USARockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA
Zhang, Wenzhu
Selimi, Fekrije
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机构:
Coll France, CIRB, Paris, FranceRockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA
Selimi, Fekrije
Earnheart, John C.
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机构:
Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USARockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA
Earnheart, John C.
Slimak, Marta A.
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机构:
Max Delbruck Ctr Mol Med, Mol Neurobiol Grp, Berlin, GermanyRockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA
Slimak, Marta A.
Santos-Torres, Julio
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机构:
Max Delbruck Ctr Mol Med, Mol Neurobiol Grp, Berlin, GermanyRockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA
Santos-Torres, Julio
Ibanez-Tallon, Ines
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机构:
Max Delbruck Ctr Mol Med, Mol Neurobiol Grp, Berlin, GermanyRockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA
Ibanez-Tallon, Ines
Aoki, Chiye
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机构:
NYU, Ctr Neural Sci, New York, NY 10003 USARockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA
Aoki, Chiye
Chait, Brian T.
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Rockefeller Univ, Lab Mass Spectrometry & Gaseous Ion Chem, New York, NY 10021 USARockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA
Chait, Brian T.
Heintz, Nathaniel
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机构:
Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USARockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA
机构:
Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Univ British Columbia, Dept Psychiat, Vancouver, BC V6T 2B5, CanadaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Zhang, Peng
Craig, Ann Marie
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机构:
Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Univ British Columbia, Dept Psychiat, Vancouver, BC V6T 2B5, CanadaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada