A new view of V(D)J recombination

被引：20
|
作者：
Gellert, M [1 ]
机构：
[1] NIDDKD,MOL BIOL LAB,BETHESDA,MD 20892
来源：
GENES TO CELLS | 1996年 / 1卷 / 03期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1046/j.1365-2443.1996.22023.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The DNA rearrangement that assembles antibody and T cell receptor genes is beginning to be understood. New work shows that the first step is a site-specific cleavage which can be performed by purified RAG1 and RAG2 proteins. The later steps largely overlap with the repair of radiation-induced DNA double-strand breaks, as indicated by the identity of several newly cloned factors. These developments open the way for a thorough biochemical study of V(D)J recombination.
引用
收藏
页码：269 / 275
页数：7
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