A new view of V(D)J recombination

被引：20
|
作者：
Gellert, M [1 ]
机构：
[1] NIDDKD,MOL BIOL LAB,BETHESDA,MD 20892
来源：
GENES TO CELLS | 1996年 / 1卷 / 03期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1046/j.1365-2443.1996.22023.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The DNA rearrangement that assembles antibody and T cell receptor genes is beginning to be understood. New work shows that the first step is a site-specific cleavage which can be performed by purified RAG1 and RAG2 proteins. The later steps largely overlap with the repair of radiation-induced DNA double-strand breaks, as indicated by the identity of several newly cloned factors. These developments open the way for a thorough biochemical study of V(D)J recombination.
引用
收藏
页码：269 / 275
页数：7
相关论文
共 50 条
  • [1] A new twist on V(D)J recombination
    Dyda, Fred
    Rice, Phoebe A.
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2018, 25 (08) : 648 - 649
  • [2] A NEW BREAK IN V(D)J RECOMBINATION
    FERGUSON, SE
    THOMPSON, CB
    CURRENT BIOLOGY, 1993, 3 (01) : 51 - 53
  • [3] A new twist on V(D)J recombination
    Fred Dyda
    Phoebe A. Rice
    Nature Structural & Molecular Biology, 2018, 25 : 648 - 649
  • [4] V(D)J recombination
    Schatz, DG
    IMMUNOLOGICAL REVIEWS, 2004, 200 : 5 - 11
  • [5] V(D)J recombination
    Sekiguchi, J
    Frank, K
    CURRENT BIOLOGY, 1999, 9 (22) : R835 - R835
  • [6] Artemis sheds new light on V(D)J recombination
    Le Deist, F
    Poinsignon, C
    Moshous, D
    Fischer, A
    de Villartay, JP
    IMMUNOLOGICAL REVIEWS, 2004, 200 : 142 - 155
  • [7] V(D)J recombination RAG recombination centres
    Leavy, Olive
    NATURE REVIEWS IMMUNOLOGY, 2010, 10 (06) : 383 - 383
  • [8] Mechanism of V(D)J recombination
    Zhu, C
    Roth, DB
    CANCER SURVEYS, 1996, 28 : 295 - 309
  • [9] The origins of V(D)J recombination
    Lewis, SM
    Wu, GE
    CELL, 1997, 88 (02) : 159 - 162
  • [10] Biochemistry of V(D)J recombination
    Schatz, DG
    Spanopoulou, E
    MOLECULAR ANALYSIS OF B LYMPHOCYTE DEVELOPMENT AND ACTIVATION, 2005, 290 : 49 - 85
12345