State estimation and predictive control of fed-batch cultures of hybridoma cells

被引：29

作者：

Dewasme, L. ^{[1
]}

Fernandes, S. ^{[1
]}

Amribt, Z. ^{[2
]}

Santos, L. O. ^{[3
]}

Bogaerts, Ph. ^{[2
]}

Vande Wouwer, A. ^{[1
]}

机构：

[1] Univ Mons, Biosci Inst, BioSys Ctr, Control Dept, B-7000 Mons, Belgium

[2] Univ Libre Bruxelles, Brussels Sch Engn, BioControl 3BIO, B-1050 Brussels, Belgium

[3] Univ Coimbra, Fac Sci & Technol, Dept Chem Engn, CIEPQPF, P-3000 Coimbra, Portugal

来源：

JOURNAL OF PROCESS CONTROL | 2015年 / 30卷

关键词：

Hybridoma cultures; Nonlinear model predictive control; Unscented Kalman filtering; Biotechnology; EXTENDED KALMAN FILTER; OVERFLOW METABOLISM; NONLINEAR-SYSTEMS; SACCHAROMYCES-CEREVISIAE; SOFTWARE SENSORS; MODEL; OPTIMIZATION; CULTIVATION; GLUCOSE; OBSERVABILITY;

D O I：

10.1016/j.jprocont.2014.12.006

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

Fed-batch cultures of hybridoma cells are commonly used for the production of monoclonal antibodies (MAb). In this study, a simple macroscopic model of the cell culture is used, which is based on the overflow metabolism paradigm. This allows to specify optimal culture conditions, and the natural formulation of a nonlinear model predictive control strategy (NMPC). As not all the component concentrations are available for measurement, system observability is analyzed, and an unscented Kalman filter (UKF) is designed, which provides satisfactory estimates of glucose and glutamine concentrations. Robustness of the NMPC scheme is investigated, as well as the combined UKF+NMPC scheme, through a minimax robust version and the closed-loop system. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：50 / 57

页数：8

共 50 条

[41] Production of cellulase in fed-batch cultures
Nanjing Forestry Univ, Nanjing, China
Linchan Huaxue Yu Gongye/Chemistry and Industry of Forest Products, 1998, 18 (02): : 73 - 77
[42] Improving an on-line feeding strategy for fed-batch cultures of hybridoma cells by dialysis and 'Nutrient-Split'-feeding
Schwabe, JO
Pörtner, R
Märkl, H
BIOPROCESS ENGINEERING, 1999, 20 (06): : 475 - 484
[43] Nonlinear multiple model predictive control in a fed-batch reactor
Santos, AIG
Johansen, TA
Cosme, JMZ
ARTIFICIAL INTELLIGENCE IN REAL-TIME CONTROL 2000, 2001, : 195 - 200
[44] Parameter estimation of a dynamic model of Escherichia coli fed-batch cultures
Retamal, C.
Dewasme, L.
Hantson, A-L
Vande Wouwer, A.
BIOCHEMICAL ENGINEERING JOURNAL, 2018, 135 : 22 - 35
[45] Model Predictive Control of a Nonlinear Fed-Batch Fermentation Process
Ashoori, Ahmad
Ghods, Amir Hosein
Khaki-Sedigh, Ali
Bakhtiari, Mohammad Reza
2008 10TH INTERNATIONAL CONFERENCE ON CONTROL AUTOMATION ROBOTICS & VISION: ICARV 2008, VOLS 1-4, 2008, : 1397 - +
[46] Batch and fed-batch cultures for the treatment of whey with mixed yeast cultures
Cristiani-Urbina, E
Netzahuatl-Muñoz, AR
Manriquez-Rojas, FJ
Juárez-Ramírez, C
Ruiz-Ordaz, N
Galíndez-Mayer, J
PROCESS BIOCHEMISTRY, 2000, 35 (07) : 649 - 657
[47] Nonlinear model predictive control of fed-batch cultures of micro-organisms exhibiting overflow metabolism
Santos, Lino O.
Dewasme, Laurent
Hantson, Anne-Lise
Wouwer, Alain Vande
2010 IEEE INTERNATIONAL CONFERENCE ON CONTROL APPLICATIONS, 2010, : 1608 - 1613
[48] On-line state estimation and identification of a fed-batch bioprocess
Selisteanu, Dan
Popescu, Dorin
Barbu, Cristina
PROCEEDINGS OF THE 9TH WSEAS INTERNATIONAL CONFERENCE ON MATHEMATICAL AND COMPUTATIONAL METHODS IN SCIENCE AND ENGINEERING (MACMESE '07)/ DNCOCO '07, 2007, : 85 - 90
[49] FED-BATCH CULTURE OF HYBRIDOMA CELLS - COMPARISON OF OPTIMAL-CONTROL APPROACH AND CLOSED-LOOP STRATEGIES
DETREMBLAY, M
PERRIER, M
CHAVARIE, C
ARCHAMBAULT, J
BIOPROCESS ENGINEERING, 1993, 9 (01): : 13 - 21
[50] Fed-batch culture of WuT3 hybridoma cells with controlling glucose concentrations
Zhang, Li
Shen, Hong
Zhang, Yuanxing
Huadong Ligong Daxue Xuebao /Journal of East China University of Science and Technology, 2000, 26 (03): : 274 - 278

← 1 2 3 4 5 →