Synthesis of 3-Substituted 2-Aminopyridines via Displacement of 3-Fluoro-2-nitropyridine

被引：2
|
作者：
Culshaw, Janet D. [1 ]
Eden, Jonathan M. [1 ]
Ford, Susannah J. [1 ]
Hayter, Barry [1 ]
Perkins, David R. [1 ]
Pike, Kurt G. [1 ]
机构：
[1] AstraZeneca, Oncol iMed, Macclesfield SK10 4TG, Cheshire, England
来源：
SYNLETT | 2012年 / 12期
关键词：
nitrogen-containing heterocycles; 3-fluoro-2-nitropyridine; 3-substituted; 2-aminopyridines; aliphatic amines; INHIBITORS;
D O I：
10.1055/s-0031-1290397
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the substitution of 3-fluoro-2-nitropyridine with a range of nitrogen-containing heterocycles and aliphatic amines is described. The reaction proceeds in a regioselective manner at moderate temperature and in reasonable yield.
引用
收藏
页码：1816 / 1820
页数：5
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