Association between bleomycin hydrolase and Alzheimer's disease in Caucasians

被引：34

作者：

Farrer, LA

Abraham, CR

Haines, JL

Rogaeva, EA

Song, YQ

McGraw, WT

Brindle, N

Premkumar, S

Scott, WK

Yamaoka, LH

Saunders, AM

Roses, AD

Auerbach, SA

Sorbi, S

Duara, R

Pericak-Vance, MA

St George-Hyslop, PH

机构：

[1] Boston Univ, Sch Med, Genet Program, Dept Med, Boston, MA 02118 USA

[2] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

[3] Boston Univ, Sch Med, Dept Epidemiol & Biostat, Boston, MA 02118 USA

[4] Boston Univ, Sch Med, Dept Biochem, Boston, MA 02118 USA

[5] Vanderbilt Univ, Program Human Genet, Nashville, TN USA

[6] Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON, Canada

[7] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[8] Univ Florence, Dept Neurol, Florence, Italy

[9] Univ Florence, Dept Psychiat, Florence, Italy

[10] Mt Sinai Med Ctr, Wien Ctr, Dept Neurol, Miami, FL USA

来源：

ANNALS OF NEUROLOGY | 1998年 / 44卷 / 05期

关键词：

D O I：

10.1002/ana.410440515

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A recent study showed modest evidence for an increased frequency of the bleomycin hydrolase (BH) VN genotype in Alzheimer's disease (AD) patients compared with nondemented controls. To test this hypothesis, we examined this polymorphism in 621 rigorously evaluated patients and 502 control subjects (all caucasian) but were unable to detect an association between BH and AD even after controlling for age, gender, and apolipoprotein E (ApoE) genotype. We conclude that this polymorphism does not account for inherited susceptibility to AD in the populations represented in this sample.

引用

页码：808 / 811

页数：4

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