Polycyclitols: synthesis of novel carbasugar and conduritol analogues as potential glycosidase inhibitors

被引：49
|
作者：
Mehta, G [1 ]
Ramesh, SS [1 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 10期
关键词：
cyclitols; carbohydrate mimetics; enzyme inhibitors; osmylation;
D O I：
10.1016/S0040-4039(01)00050-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Stereoselective syntheses of a new family of hydrindane based bicyclitols with seven hydroxyl groups in a diverse stereochemical array have been accomplished from readily available building-blocks. One of the bicyclitols 12 has been found to exhibit moderate alpha -glucosidase inhibitory activity in enzymatic assays. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1987 / 1990
页数：4
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