Polycyclitols. Novel conduritol and carbasugar hybrids as a new class of potent glycosidase inhibitors

被引：81
|
作者：
Mehta, G [1 ]
Ramesh, SS [1 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India
来源：
CHEMICAL COMMUNICATIONS | 2000年 / 24期
关键词：
D O I：
10.1039/b007224i
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have conceptualized new molecular entities (bicyclitols) in which two conduritol and two carbasugar moieties are embedded in a polyhydroxylated decahydronaphthalene framework and achieved their syntheses in a stereo- and regioselective manner. One of the bicyclitols was found to be a potent and selective alpha -glucosidase inhibitor.
引用
收藏
页码：2429 / 2430
页数：2
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