Amyloid β-peptide(25-35) changes [Ca2+] in hippocampal neurons

被引：51
|
作者：
Mogensen, HS [1 ]
Beatty, DM
Morris, SJ
Jorgensen, OS
机构：
[1] Univ Copenhagen, Dept Pharmacol, Lab Neuropsychiat, DK-2100 Copenhagen, Denmark
[2] Rigshosp, DK-2100 Copenhagen, Denmark
[3] Univ Missouri, Div Mol Biol & Biochem, Kansas City, MO 64110 USA
来源：
NEUROREPORT | 1998年 / 9卷 / 07期
关键词：
Alzheimer's disease; amyloid beta-peptide; calcium ion; hydrogen ion; hippocampal neurons; rat;
D O I：
10.1097/00001756-199805110-00057
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
INSOLUBLE aggregates of the amyloid p-peptide (AP) is a major constituent of senile plaques found in brains of Alzheimer disease (AD) patients. The detrimental effects of aggregated A beta is associated with an increased intracellular Ca2+ concentration ([Ca2+](i)). We examined the effects of AP(25-35) on [Ca2+](i) and intracellular H+ concentration ([H+](i)) in single hippocampal neurons by real time fluorescence imaging using the Ca2+- and H+-specific ratio dyes, indo-1 and SNARF-1. Incubation of these cultures with AP(25-35) for 3-12 days in vitro increased [Ca2+](i) and [H+](i) in large, NMDA-responsive neurons. (C) 1998 Rapid Science Ltd.
引用
收藏
页码：1553 / 1558
页数：6
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