Synthesis New Benzimidazole Derivatives as Antibacterial

被引：5

作者：

Mohsen, Dehyaa Hussain ^{[1
]}

Radhi, Ali Jabbar ^{[1
,2
]}

Shaheed, Dhurgham Qasim ^{[2
]}

Abbas, Hayder Kadhim ^{[2
]}

机构：

[1] Minist Educ, Gen Directorate Educ Najaf Al Ashraf, Najaf, Iraq

[2] Univ Alkafeel, Coll Pharm, Najaf, Iraq

来源：

JOURNAL OF PHARMACEUTICAL NEGATIVE RESULTS | 2022年 / 13卷

关键词：

Benzimidazole; Resistant Bacteria; 1,2,3-Triazole; Antibiotic; Benzimidazolium Salts; ANTIMICROBIAL ACTIVITY; IN-VITRO; ANTIOXIDANT PROPERTIES; BIOLOGICAL EVALUATION; ANTIPROTOZOAL; INHIBITORS; COMPLEXES; AGENTS; RING;

D O I：

10.47750/pnr.2022.13.S03.137

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

N-substituted alkylbenzimidazole derivatives connected to 1,2,3-triazole through methlene linkers (tb1, tb2, tb3, tb4 and tb5) were prepared and designed with the goal of estimating their anti-organism activity such as anti-bacterial activity. FTIR and NMR spectroscopies were used to analyzed the prepared compounds. The biological potential of these substances was examined for antibacterial activity against tow type of microorganisms, the first [gram-negative (Escherichia Coll)] and the second [gram-positive (Staphylococcus Aureus)]. Compared with Gram-negative bacteria, all compounds showed a strong effect against Gram-positive bacteria.

引用

页码：893 / 898

页数：6

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