Ruthenium-catalyzed oxidative cyanation of tertiary amines with hydrogen peroxide and sodium cyanide

被引：244
|
作者：
Murahashi, SI [1 ]
Komiya, N [1 ]
Terai, H [1 ]
机构：
[1] Osaka Univ, Grad Sch Engn Sci, Dept Chem, Toyonaka, Osaka 5608531, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 42期
关键词：
arnines; cyanides; hydrogen peroxide; oxidation; ruthenium;
D O I：
10.1002/anie.200501496
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Versatile intermediates for the synthesis of N-aryl-α-amino acids and N,N-disubstituted 1,2-diamines can now be synthesized with high efficiency by the ruthenium-catalyzed oxidative cyanation of tertiary amines. The use of hydrogen peroxide as an oxidant in the presence of NaCN/AcOH or HCN provides the corresponding α-aminonitriles (see reaction). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：6931 / 6933
页数：3
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