Potassium Thiocyanate as Source of Cyanide for the Oxidative α-Cyanation of Tertiary Amines

被引：63
|
作者：
Wagner, Alexander [1 ]
Ofial, Armin R. [1 ]
机构：
[1] Univ Munich, Dept Chem, D-81377 Munich, Germany
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 05期
关键词：
DEHYDROGENATIVE COUPLING REACTIONS; C-H FUNCTIONALIZATION; HYDROGEN-PEROXIDE; HIGHLY EFFICIENT; ANODIC CYANATION; ELECTROCHEMICAL OXIDATION; ION; NITRILES; CATALYST; BONDS;
D O I：
10.1021/jo502846c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Oxidation at the sulfur of the safe-to-handle potassium thiocyanate releases cyanide units that are trapped in the presence of co-oxidized tertiary amines to form a-amino nitriles. These cyanations work in aqueous solutions and do not require a catalyst, nor do they form toxic byproducts.
引用
收藏
页码：2848 / 2854
页数：7
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