Evidence for the Natural Toxins from the Mushroom Trogia venenata as a Cause of Sudden Unexpected Death in Yunnan Province, China

被引：51

作者：

Zhou, Zhong-Yu ^{[2
,4
]}

Shi, Guo-Qing ^{[1
]}

Fontaine, Robert ^{[1
,3
]}

Wei, Kun ^{[2
]}

Feng, Tao ^{[2
]}

Wang, Fang ^{[2
]}

Wang, Gang-Qiang ^{[2
]}

Qu, Yan ^{[2
]}

Li, Zheng-Hui ^{[2
]}

Dong, Ze-Jun ^{[2
]}

Zhu, Hua-Jie ^{[2
]}

Yang, Zhu-Liang ^{[2
]}

Zeng, Guang ^{[1
]}

Liu, Ji-Kai ^{[2
]}

机构：

[1] Chinese Ctr Dis Control & Prevent, Beijing 100050, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[3] US Ctr Dis Control & Prevent, Atlanta, GA 30333 USA

[4] Chinese Acad Sci, S China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 10期

关键词：

amino acids; mushrooms; natural products; toxicology; GAMMA-GUANIDINOBUTYRIC ACID; METHYLENECYCLOPROPYLGLYCINE;

D O I：

10.1002/anie.201106502

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Life saver: Two unusual and toxic amino acids, 2R-amino-4S-hydroxy-5- hexynoic acid (red, see scheme) and 2R-amino-5-hexynoic acid (blue) have been isolated from the fruiting bodies of the mushroom Trogia venenata. Toxicology studies suggest that these compounds may be the cause of Sudden Unexplained Death (SUD) in Yunnan Province, China. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2368 / 2370

页数：3

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