First Intramolecular Alkylation of Nitriles with Primary and Secondary Alcohols Catalyzed by Iridium Complexes

被引：27
|
作者：
Anxionnat, Bruno [1 ]
Pardo, Domingo Gomez [1 ]
Ricci, Gino [2 ]
Cossy, Janine [1 ]
机构：
[1] ESPCI ParisTech, Chim Organ Lab, F-75005 Paris, France
[2] Sanofi, Proc Dev, F-04210 Sisteron, France
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 24期
关键词：
Iridium; Homogeneous catalysis; Alkylation; Hydrogen transfer; Nitriles; DIRECT ALPHA-ALKYLATION; MONOALKYLATION; ARYLACETONITRILES; ACETONITRILE; CYCLIZATIONS; KETONES;
D O I：
10.1002/ejoc.201200850
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first iridium-catalyzed intramolecular alkylation ofnitriles with primary and secondary alcohols through hydrogen transfer is described. This reaction allows access to precursors of biologically active arylmethylamines.
引用
收藏
页码：4453 / 4456
页数：4
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