Synthesis of oxadiazolylindole derivatives and their antiinflammatory activity

被引：0
|
作者：
Sonar, VN [1 ]
Yazadan, SK [1 ]
Sreenivasulu, N [1 ]
机构：
[1] VL Coll Pharm, Dept Pharmaceut Chem, Raichur 584101, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2001年 / 10卷 / 04期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Substituted indole-2-carboxylates (1) were reacted with hydrazine hydrate to furnish corresponding indole-2-carboxyhydrazides (2). The hydrazides 2 when allowed to react with CS, in the presence of KOH gave respective 2-(5 ' -thioxo-1 ' ,3 ' ,4 ' -oxadiazol-2 ' -yl) indoles (3) which undergo Mannich reaction with amines in presence of formaldehyde to yield 4. Synthesized compounds were screened for their antiinflammatory activity.
引用
收藏
页码：299 / 302
页数：4
相关论文
共 50 条
  • [31] HYDROXAMIC AND AMIDE DERIVATIVES OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS - SYNTHESIS AND BIOLOGICAL ACTIVITY
    Rajic, Zrinca
    Zorc, Branka
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 38 (01) : 46 - 47
  • [32] SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME INDAZOLE DERIVATIVES .36. AZOLES
    WRZECIONO, U
    LINKOWSKA, E
    MAJEWSKA, K
    GZELLA, A
    STOCHLA, K
    PHARMAZIE, 1993, 48 (08): : 582 - 584
  • [33] SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF 2-PYRIDYL-2-THIOBENZOTHIAZOLE DERIVATIVES
    LAGORCE, JF
    LAKHDAR, M
    FATIMI, J
    NEFAOUI, S
    RABY, C
    FARMACO, 1992, 47 (12): : 1477 - 1485
  • [34] BENZIMIDAZOLE DERIVATIVES WITH ATYPICAL ANTIINFLAMMATORY ACTIVITY
    LAZER, ES
    MATTEO, MR
    POSSANZA, GJ
    JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (04) : 726 - 729
  • [35] ANTIINFLAMMATORY ACTIVITY OF 2 PHENYLINDANDIONE DERIVATIVES
    ROSINI, S
    TRALLORI, L
    FARMACO-EDIZIONE SCIENTIFICA, 1976, 31 (06): : 403 - 411
  • [36] ANTIINFLAMMATORY ACTIVITY OF SOME PYRAZOLE DERIVATIVES
    MAKHSUMOV, AG
    DZHURAEV, AD
    KILICHOV, G
    NIKBAEV, AT
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1986, 20 (03): : 289 - 291
  • [37] Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide
    Machado, AL
    Lima, LM
    Araujo, JX
    Fraga, CAM
    Koatz, VLG
    Barreiro, EJ
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (04) : 1169 - 1172
  • [38] Synthesis and antiinflammatory activity of novel 2,5-disubstituted thiophene derivatives
    Badr, Sahar Mohamed Ibrahim
    TURKISH JOURNAL OF CHEMISTRY, 2011, 35 (01) : 131 - 143
  • [39] SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF ANTIOXIDANTS, 4-ALKYLTHIO-ORTHO-ANISIDINE DERIVATIVES
    KOMESHIMA, N
    OSAWA, T
    NISHITOBA, T
    JINNO, Y
    KIRIU, T
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, 40 (02) : 351 - 356
  • [40] Synthesis of Bis-Enone Derivatives and Evaluation of their Antiinflammatory Activity on Respiratory Infection
    Zheng, Mingxing
    Zhu, Zhibing
    LATIN AMERICAN JOURNAL OF PHARMACY, 2016, 35 (09): : 2084 - 2087
12345