Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilides

被引：11
|
作者：
Ali, Abdelselam [1 ]
Altamore, Timothy M. [1 ]
Bliese, Marianne [1 ]
Fisara, Petr [2 ]
Liepa, Andris J. [1 ]
Meyer, Adam G. [1 ]
Nguyen, Oahn [1 ]
Sargent, Roger M. [2 ]
Sawutz, David G. [3 ]
Winkler, David A. [1 ]
Winzenberg, Kevin N. [1 ]
Ziebell, Angela [1 ]
机构：
[1] CSIRO Mol & Hlth Technol, Clayton, Vic 3169, Australia
[2] Schering Plough Pty Ltd, Baulkham Hills, NSW 2153, Australia
[3] Schering Plough Res Inst, Kenilworth, NJ 07033 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 01期
关键词：
trifluoromethanesulfonanilide; oxime ether; parasiticide; Ctenocephalides felis (cat flea); Rhipicephalus sanguineus (brown dog tick); Haemonchus contortus;
D O I：
10.1016/j.bmcl.2007.10.090
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilide derivatives have shown significant in vitro parasiticidal activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. A number of these compounds also displayed significant in vitro endoparasite activity against the nematode Haemonchus contortus. Crown copyright (C) 2007 Published by Elsevier Ltd. All rights reserved.
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页码：252 / 255
页数：4
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