Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilides

被引：11

作者：

Ali, Abdelselam ^{[1
]}

Altamore, Timothy M. ^{[1
]}

Bliese, Marianne ^{[1
]}

Fisara, Petr ^{[2
]}

Liepa, Andris J. ^{[1
]}

Meyer, Adam G. ^{[1
]}

Nguyen, Oahn ^{[1
]}

Sargent, Roger M. ^{[2
]}

Sawutz, David G. ^{[3
]}

Winkler, David A. ^{[1
]}

Winzenberg, Kevin N. ^{[1
]}

Ziebell, Angela ^{[1
]}

机构：

[1] CSIRO Mol & Hlth Technol, Clayton, Vic 3169, Australia

[2] Schering Plough Pty Ltd, Baulkham Hills, NSW 2153, Australia

[3] Schering Plough Res Inst, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 01期

关键词：

trifluoromethanesulfonanilide; oxime ether; parasiticide; Ctenocephalides felis (cat flea); Rhipicephalus sanguineus (brown dog tick); Haemonchus contortus;

D O I：

10.1016/j.bmcl.2007.10.090

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilide derivatives have shown significant in vitro parasiticidal activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. A number of these compounds also displayed significant in vitro endoparasite activity against the nematode Haemonchus contortus. Crown copyright (C) 2007 Published by Elsevier Ltd. All rights reserved.

引用

页码：252 / 255

页数：4

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