The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses

被引：144
|
作者：
Tumpey, Terrence M.
Szretter, Kristy J.
Van Hoeven, Neal
Katz, Jacqueline M.
Kochs, Georg
Haller, Otto
Garcia-Sastre, Adolfo
Staeheli, Peter
机构：
[1] Univ Freiburg, Dept Virol, D-79104 Freiburg, Germany
[2] Ctr Dis Control, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA
[3] CUNY Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA
[4] CUNY Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA
[5] CUNY Mt Sinai Sch Med, Div Infect Dis, Emerging Pathogens Inst, New York, NY 10029 USA
来源：
JOURNAL OF VIROLOGY | 2007年 / 81卷 / 19期
关键词：
D O I：
10.1128/JVI.01116-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Mice carrying a wild-type Mx1 gene (Mx1(+/+)) differ from standard laboratory mice (Mx1(-/-)) in being highly resistant to infection with common laboratory strains of influenza A virus. We report that Mx1 also protects mice against the pandemic human 1918 influenza virus and a highly lethal human H5N1 strain from Vietnam. Resistance to H5N1 of Mx1(+/+) but not Mx1(-/-) mice was enhanced if the animals were treated with a single dose of exogenous alpha interferon before infection. Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses.
引用
收藏
页码：10818 / 10821
页数：4
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