Ca2+-sensitization of contraction in the h1 calponin-deficient smooth muscle

被引：7
|
作者：
Yoshimoto, R
Hori, M
Takahashi, K
Taniguchi, S
Katsuki, M
Ozaki, H
Karaki, H [1 ]
机构：
[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Pharmacol, Tokyo 1138511, Japan
[2] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Med, Osaka 5378511, Japan
[3] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan
[4] Japan Sci & Technol Corp, PRESTO, Tokyo, Japan
[5] Shinshu Univ, Sch Med, Res Ctr Aging & Adaptat, Nagano 6570013, Japan
[6] Univ Tokyo, Inst Med Sci, Dept DNA Biol & Embryo Engn, Tokyo 1088639, Japan
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 2000年 / 84卷 / 04期
关键词：
calponin; Ca2+-sensitization; smooth muscle contraction;
D O I：
10.1254/jjp.84.474
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Role of h1 calponin on Ca2+-sensitivity of smooth muscle contraction was investigated using h1 calponin gene-deficient mice (CP -/-) and wild type mice (CP+/+). PGF(2 alpha) induced a comparable force in intact aorta of CP +/+ and CP -/-. DPB showed similar effects to PGF(2 alpha). In membrane-permeabilized ileal smooth muscle, PDBu enhanced Ca2+-sensitivity of contraction comparably in CP +/+ and CP -/-. GTP gamma -S showed similar effects. Our results suggest that h1 calponin does not regulate Ca2+-sensitivity in the contractile mechanism of smooth muscle.
引用
收藏
页码：474 / 475
页数：2
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