Ca2+-sensitization of contraction in the h1 calponin-deficient smooth muscle

被引：7

作者：

Yoshimoto, R

Hori, M

Takahashi, K

Taniguchi, S

Katsuki, M

Ozaki, H

Karaki, H ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Pharmacol, Tokyo 1138511, Japan

[2] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Med, Osaka 5378511, Japan

[3] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[4] Japan Sci & Technol Corp, PRESTO, Tokyo, Japan

[5] Shinshu Univ, Sch Med, Res Ctr Aging & Adaptat, Nagano 6570013, Japan

[6] Univ Tokyo, Inst Med Sci, Dept DNA Biol & Embryo Engn, Tokyo 1088639, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 2000年 / 84卷 / 04期

关键词：

calponin; Ca2+-sensitization; smooth muscle contraction;

D O I：

10.1254/jjp.84.474

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Role of h1 calponin on Ca2+-sensitivity of smooth muscle contraction was investigated using h1 calponin gene-deficient mice (CP -/-) and wild type mice (CP+/+). PGF(2 alpha) induced a comparable force in intact aorta of CP +/+ and CP -/-. DPB showed similar effects to PGF(2 alpha). In membrane-permeabilized ileal smooth muscle, PDBu enhanced Ca2+-sensitivity of contraction comparably in CP +/+ and CP -/-. GTP gamma -S showed similar effects. Our results suggest that h1 calponin does not regulate Ca2+-sensitivity in the contractile mechanism of smooth muscle.

引用

页码：474 / 475

页数：2

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